Water → 3-(2-Carboxypyridin-6-yl)-6-(pyridin-2-yl)-pyridazine

HRID 574190ノート

反応式

HRID 574190 の反応式
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[N:9]=[N:10][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)=[CH:12][CH:13]=2)[CH:5]=[CH:4][CH:3]=1.[Se](=O)=[O:21].ClC1C=CC=CC=1Cl.[OH2:31]>>[C:1]([C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([C:8]2[N:9]=[N:10][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)=[CH:12][CH:13]=2)[N:7]=1)([OH:21])=[O:31]

参加物

5

反応物 4

HCID 962WaterHCID 72391,2-DichlorobenzeneHCID 24007Selenium DioxideHCID 64179693-(6-Methylpyridin-2-yl)-6-(pyridin-2-yl)pyridazine

生成物 1

HCID 64179713-(2-Carboxypyridin-6-yl)-6-(pyridin-2-yl)-pyridazine収率 74%

反応条件

温度
150 °C

実験手順

400 mg (2.42 mmol) of pyridazine 44, 177 mg (1.60 mmol) of selenium dioxide and 7 ml of o-dichlorobenzene are introduced into a 100 ml round-bottomed flask equipped with a condenser. The mixture is heated at 150° C. for 4 hours, and then cooled to ambient temperature. An excess of water is added to the precipitate formed, which is filtered off and washed with water. The solid obtained is dried, so as to give the acid 45 with a yield of 74%.

後処理

  1. customequipped with a condenser
  2. temperaturecooled to ambient temperature
  3. customformed
  4. filtrationwhich is filtered off
  5. washwashed with water
  6. customThe solid obtained
  7. customis dried

出典と根拠

ORDレコード
ord-862c866f606343ffa9b1bf435279761d
出典データセット
uspto-grants-2015_05
特許番号
US09034873B2

反応ノート

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