Methyl 3-amino-5-(trifluoromethyl)pyridine-2-carboxylate → 3-Amino-5-(trifluoromethyl)picolinohydrazide

HRID 574243ノート

反応式

HRID 574243 の反応式
[NH2:1][C:2]1[C:3]([C:13]([NH:15][NH2:16])=[O:14])=[N:4][C:5](Br)=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.COC(C1C(N)=CC(C(F)(F)F)=C(Br)N=1)=O.COC(C1C(N)=CC(C(F)(F)F)=CN=1)=O>>[NH2:1][C:2]1[C:3]([C:13]([NH:15][NH2:16])=[O:14])=[N:4][CH:5]=[C:6]([C:8]([F:10])([F:9])[F:11])[CH:7]=1

参加物

4

反応物 3

HCID 58964419Methyl 3-amino-5-(trifluoromethyl)pyridine-2-carboxylate2 回HCID 58964428Methyl 3-amino-6-bromo-5-(trifluoromethyl)picolinateHCID 867295953-Amino-6-bromo-5-(trifluoromethyl)picolinohydrazide

生成物 1

HCID 867296013-Amino-5-(trifluoromethyl)picolinohydrazide

実験手順

The title compound was prepared analogously to Intermediate H by replacing 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (Intermediate A4) with 3-Amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (Intermediate A3);

出典と根拠

ORDレコード
ord-664717366a1744a19873cba4726bcba1
出典データセット
uspto-grants-2015_05
特許番号
US09034879B2

反応ノート

読み込み中…