Methanol → HCID 66915488、化合物
反応式
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N:10]([CH3:12])[CH3:11])[CH:7]=[CH:6][C:5]=1[N+:13]([O-])=O.[CH3:17]O>[Ni]>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N:10]([CH3:12])[CH3:11])[CH:7]=[C:6]([CH3:17])[C:5]=1[NH2:13]参加物
4
実験手順
Raney Nickel (80 mg) was added to a suspension of 5-dimethylamino-2-nitro-benzoic acid methyl ester (400 mg, 1.78 mmol) in methanol (20 mL) and hydrogenated under atmospheric pressure at room temperature for 2 hr. The reaction mixture was filtered over celite and the filtrate was concentrated in vacuum to afford methyl 2-amino-5-dimethylamino-benzoic acid methyl ester (340 mg, 98%) as greenish brown liquid.
後処理
- filtrationThe reaction mixture was filtered over celite
- concentrationthe filtrate was concentrated in vacuum
出典と根拠
- ORDレコード
- ord-7f517677b5b04bd197bd60c84ae80e29
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09034887B2
反応ノート
読み込み中…