Acetic Acid → HCID 178489574、化合物

HRID 574318

反応式

HRID 574318 の反応式
[N:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH3:11])=[C:2]=[S:3].C[O:13][C:14](=O)[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:16]=1[NH2:22].C(O)(=O)C>C(O)C>[SH:3][C:2]1[N:1]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[O:10][CH3:11])[C:14](=[O:13])[C:15]2[C:16](=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=2)[N:22]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 5205992-Methoxyphenyl IsothiocyanateHCID 11205965Methyl 2-amino-4-methylbenzoate

生成物 1

HCID 178489574HCID 178489574、化合物収率 62%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

1-Isothiocyanato-2-methoxy-benzene (0.76 mL, 5.45 mmol) was added to a solution of 2-amino-4-methyl-benzoic acid methyl ester (900 mg, 5.45 mmol) and acetic acid (1.5 mL) in ethanol (10 mL), and heated at reflux for 16 hr. The reaction mixture was cooled to room temperature and diluted with ethanol. The precipitated solid was filtered, washed with ethanol and dried to afford 2-mercapto-3-(2-methoxy-phenyl)-7-methyl-3H-quinazolin-4-one (1.0 g, 62%) as white solid.

後処理

  1. temperatureheated
  2. temperatureat reflux for 16 hr
  3. filtrationThe precipitated solid was filtered
  4. washwashed with ethanol
  5. customdried

出典と根拠

ORDレコード
ord-f00a564f82cb40d49009fa43b4a6a418
出典データセット
uspto-grants-2015_05
特許番号
US09034887B2

関連ノート

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