p-Toluenesulfonic acid monohydrate → 7-bromo-5-fluoro-1H-indene
反応式
[Br:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2O.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]2[C:3]=1[CH2:4][CH:5]=[CH:6]2参加物
4
実験手順
According to Scheme 2, step 2: A mixture of 4-bromo-6-fluoro-indan-1-ol (4a) (10.0 g, 43.3 mmol) and para-toluene sulfonic acid monohydrate (372 mg, 2.16 mmol) in toluene was heated at reflux for 2.5 h. The solution was washed with aqueous saturated NaHCO3 and brine, dried over MgSO4 and solvents evaporated to give 9.0 g of 7-Bromo-5-fluoro-1H-indene (5a) which was used immediately in the next step without purification.
後処理
- temperaturewas heated
- temperatureat reflux for 2.5 h
- washThe solution was washed with aqueous saturated NaHCO3 and brine
- dry with materialdried over MgSO4 and solvents
- customevaporated
出典と根拠
- ORDレコード
- ord-b4dcc7b80f3d418a813895f273aa228f
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09034897B2
反応ノート
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