Diethyl Ether → HCID 178418743、化合物

HRID 574696

反応式

HRID 574696 の反応式
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][OH:11])=[CH:9][C:4]=2[N:3]=[CH:2]1.C[N+]1([O-])CCOCC1.CCOCC>ClCCl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=[O:11])=[CH:9][C:4]=2[N:3]=[CH:2]1

参加物

6

反応物 3

HCID 3283Diethyl EtherHCID 82029Methyl morpholine oxideHCID 178519339HCID 178519339、化合物

生成物 1

HCID 178418743HCID 178418743、化合物

試薬・触媒・溶媒 2

HCID 178419074HCID 178419074、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

(1H-benzo[d]imidazole-5-yl)methanol (2.8 mmol, 1 eq.) was dissolved in 30 mL dichloromethane and a molecular sieve (4 A) was added. To the solution were added Tetrapropylammonium perruthenate (0.28 mmol, 0.1 eq.) and N-Methylmorpholine-N-Oxide (9.8 mmol, 3.5 eq.). After stirring the mixture for 72 hours at room temperature 50 mL of ether was added and filtrated. The solvent was removed under reduced pressure and the product was purified by means of flash-chromatography using silica gel and a ethyl acetate/MeOH-gradient.

後処理

  1. additiona molecular sieve (4 A) was added
  2. additionwas added
  3. filtrationfiltrated
  4. customThe solvent was removed under reduced pressure
  5. customthe product was purified by means of flash-chromatography

出典と根拠

ORDレコード
ord-12dc541905d04133a437a9cab93dbb56
出典データセット
uspto-grants-2015_05
特許番号
US09034907B2

関連ノート

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