4-[3-(Dimethylamino)propoxy]benzonitrile → 4-[3-(Dimethylamino)propoxy]benzylamine

HRID 574851ノート

反応式

HRID 574851 の反応式
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1>CO.[Ni]>[NH2:12][CH2:11][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:1])[CH3:15])=[CH:14][CH:13]=1

参加物

4

反応物 1

HCID 118583624-[3-(Dimethylamino)propoxy]benzonitrile

生成物 1

HCID 214653844-[3-(Dimethylamino)propoxy]benzylamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

4-(3-(Dimethylamino)propoxy)benzonitrile (300 mg) in methanol (20 mL) was treated with Raney nickel (wet, 1.5 g) under H2 (30 psi) for 4 hour. The insoluble material was filtered off and the filtrate was concentrated to provide the title compound.

後処理

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-3e6a40bfeb16469da8fd64d469e0f5d1
出典データセット
uspto-grants-2015_05
特許番号
US09034875B2

反応ノート

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