Water → HCID 67126688、化合物

HRID 574943ノート

反応式

HRID 574943 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]1([F:24])[CH2:15][CH2:14][C:13]2(OC3C=CC=CC=3[O:16]2)[CH2:12][CH2:11]1.C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.O>CC(C)=O.ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]1([F:24])[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]1

参加物

6

反応物 3

HCID 962WaterHCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 671269175-Chloro-6-((4'-fluoro spiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]-4'-yl)methoxy)pyridine-3-sulfonamide

生成物 1

HCID 67126688HCID 67126688、化合物

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 6344Dichloromethane溶媒

反応条件

温度
100 °C

実験手順

To a solution of EXAMPLE 350D (1.6 g) and pyridinium p-toluenesulfonate (1.2 g) in acetone (10 mL) was added water (2 mL) and the mixture was stirred under microwave irradiation at 100° C. for 10 minutes. The mixture was diluted with dichloromethane (300 mL) and washed with aqueous NaHCO3, water, brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the title compound.

後処理

  1. washwashed with aqueous NaHCO3, water, brine
  2. dry with materialdried over Na2SO4
  3. filtrationFiltration and evaporation of the solvent

出典と根拠

ORDレコード
ord-24475b5a3fd24535a21dd77726b72675
出典データセット
uspto-grants-2015_05
特許番号
US09034875B2

反応ノート

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