Bromine → 5-Bromo-4-fluoro-2-hydroxybenzaldehyde

HRID 575009

反応式

HRID 575009 の反応式
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([OH:10])[CH:3]=1.[Br:11]Br>CC(O)=O>[Br:11][C:9]1[C:2]([F:1])=[CH:3][C:4]([OH:10])=[C:5]([CH:8]=1)[CH:6]=[O:7]

参加物

4

反応物 2

HCID 24408BromineHCID 27792684-Fluoro-2-hydroxybenzaldehyde

生成物 1

HCID 71721285-Bromo-4-fluoro-2-hydroxybenzaldehyde収率 17%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
2.5 °C

実験手順

Into a 20-L 4-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen was placed a solution of 4-fluoro-2-hydroxybenzaldehyde (545 g, 3.89 mol, 1.00 equiv) in AcOH (5 L), followed by the addition of Br2 (623 g, 3.90 mol, 1.00 equiv) dropwise with stirring at 0-5° C. The resulting solution was stirred overnight at room temperature, quenched by the addition of 3 L of saturated aqueous Na2SO3 and diluted with 6 L of ice/water. The solids were collected by filtration, washed with 2×1.5 L of water and dried to afford 145 g (crude) of 5-bromo-4-fluoro-2-hydroxybenzaldehyde as a yellow solid.

後処理

  1. customInto a 20-L 4-necked round-bottom flask purged
  2. temperaturemaintained with an inert atmosphere of nitrogen
  3. stirringThe resulting solution was stirred overnight at room temperature
  4. customquenched by the addition of 3 L of saturated aqueous Na2SO3
  5. additiondiluted with 6 L of ice/water
  6. filtrationThe solids were collected by filtration
  7. washwashed with 2×1.5 L of water
  8. customdried

出典と根拠

ORDレコード
ord-01a57c2642fb4febb7760ff1e208e1a8
出典データセット
uspto-grants-2015_05
特許番号
US09034866B2

関連ノート

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