Ammonium Chloride → 10-bromo-9-fluoro-3-formyl-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide
反応式
[Br:1][C:2]1[C:15]([F:16])=[CH:14][C:13]2[CH:12]3[CH2:17][CH:10]([CH2:11]3)[N:9]3[C:5](=[N:6][C:7]([C:20](O)=[O:21])=[C:8]3[CH:18]=[O:19])[C:4]=2[CH:3]=1.[Cl-].[NH4+:24]>>[Br:1][C:2]1[C:15]([F:16])=[CH:14][C:13]2[CH:12]3[CH2:11][CH:10]([CH2:17]3)[N:9]3[C:5](=[N:6][C:7]([C:20]([NH2:24])=[O:21])=[C:8]3[CH:18]=[O:19])[C:4]=2[CH:3]=1参加物
3
実験手順
9-bromo-10-fluoro-3-formyl-2,5-diazatetracyclo[11.1.1.0[2,6].0[7,12]]pentadeca-3,5,7(12),8,10-pentaene-4-carboxylic acid (0.09 g) was reacted with ammonium chloride similar to as described in Example 2 to give 60 mg of 9-bromo-10-fluoro-3-formyl-2,5-diazatetracyclo[11.1.1.0[2,6].0[7,12]]pentadeca-3,5,7(12),8,10-pentaene-4-carboxamide.
出典と根拠
- ORDレコード
- ord-a5786cdcac094a6e814f02c1ec2f485e
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09034866B2
反応ノート
読み込み中…