2-(5-Chloropyridin-2-yl)but-3-yn-2-ol → (+/-)-10-(3-(5-Chloropyridin-2-yl)-3-hydroxybut-1-yn-1-yl)-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide

HRID 575219ノート

反応式

HRID 575219 の反応式
Br[C:2]1[C:3]([F:19])=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1.[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]([OH:31])([C:29]#[CH:30])[CH3:28])=[N:25][CH:26]=1>>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]([OH:31])([CH3:28])[C:29]#[C:30][C:2]2[C:3]([F:19])=[CH:4][C:5]3[O:11][CH2:10][CH2:9][N:8]4[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]4[C:6]=3[CH:18]=2)=[N:25][CH:26]=1

参加物

3

反応物 2

HCID 866696112-(5-Chloropyridin-2-yl)but-3-yn-2-olHCID 8669305110-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide

生成物 1

HCID 71715336(+/-)-10-(3-(5-Chloropyridin-2-yl)-3-hydroxybut-1-yn-1-yl)-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide収率 28%

実験手順

Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 2-(5-chloropyridin-2-yl)but-3-yn-2-ol to give the titled compound as a grey solid (60 mg, 28%).

出典と根拠

ORDレコード
ord-efd392e9e1ad4fec8a2dacb584665f82
出典データセット
uspto-grants-2015_05
特許番号
US09034866B2

反応ノート

読み込み中…