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(R)-2-(5-methyl-1,2,4-oxadiazol-3-yl)but-3-yn-2-ol → (R)-9-(3-hydroxy-3-(5-methyl-1,2,4-oxadiazol-3-yl)but-1-yn-1-yl)-5,6-dihydro-4H-4,6-methanobenzo[6,7]cyclohepta[1,2-d]thiazole-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (R)-2-(5-methyl-1,2,4-oxadiazol-3-yl)but-3-yn-2-ol | HCID 86669593 | — |
| 反応物 | 9-bromo-5,6-dihydro-4H-4,6-methanobenzo[6,7]cyclohepta[1,2-d]thiazole-2-carboxamide | HCID 86693314 | — |
| 生成物 | (R)-9-(3-hydroxy-3-(5-methyl-1,2,4-oxadiazol-3-yl)but-1-yn-1-yl)-5,6-dihydro-4H-4,6-methanobenzo[6,7]cyclohepta[1,2-d]thiazole-2-carboxamide | HCID 86693316 | 14% |
反応手順
Similar to as described in General Procedure G, 9-bromo-5,6-dihydro-4H-4,6-methanobenzo[6,7]cyclohepta[1,2-d]thiazole-2-carboxamide was reacted with (2R)-2-(5-methyl-1,2,4-oxadiazol-3-yl)but-3-yn-2-ol to give the titled compound as a colorless solid (5.2 mg, 14%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09034866B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-2969bd64beea4f7f9c60dd03b48562ab |
| 出典メモ | uspto-grants-2015_05 |