(Diethylamino)sulfur trifluoride → Ethyl 9-bromo-4-fluoro-4-methyl-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxylate

HRID 575290ノート

反応式

HRID 575290 の反応式
[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][CH2:7][C:8](O)([CH3:19])[C:9]3[S:13][C:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:11][C:10]=3[C:4]=2[CH:3]=1.CCN(S(F)(F)[F:29])CC.BrC1C=CC2OCC(F)(F)C3SC(C(OCC)=O)=NC=3C=2C=1>>[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][CH2:7][C:8]([F:29])([CH3:19])[C:9]3[S:13][C:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:11][C:10]=3[C:4]=2[CH:3]=1

参加物

4

反応物 3

HCID 123472(Diethylamino)sulfur trifluorideHCID 86693318Ethyl 9-bromo-4-hydroxy-4-methyl-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxylateHCID 86693319Ethyl 9-bromo-4,4-difluoro-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxylate

生成物 1

HCID 86693317Ethyl 9-bromo-4-fluoro-4-methyl-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxylate

実験手順

The title compound was prepared from ethyl 9-bromo-4-hydroxy-4-methyl-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxylate and DAST as described in the synthesis of ethyl 9-bromo-4,4-difluoro-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxylate.

出典と根拠

ORDレコード
ord-954eda9c04c44d8db6222910315764e4
出典データセット
uspto-grants-2015_05
特許番号
US09034866B2

反応ノート

読み込み中…