Formamide → HCID 86693469、化合物

反応式

[Br:1][C:2]1[C:3]([F:34])=[CH:4][C:5]2[CH:11]3[CH2:12][CH:9]([CH2:10]3)[N:8]3[C:13]([CH:20]([OH:32])[C:21]4[N:25]([CH:26]5[CH2:31][CH2:30][CH2:29][CH2:28][O:27]5)[N:24]=[CH:23][CH:22]=4)=[C:14]([C:16]([O:18]C)=O)[N:15]=[C:7]3[C:6]=2[CH:33]=1.C[O-].[Na+].C([NH2:40])=O>>[Br:1][C:2]1[C:3]([F:34])=[CH:4][C:5]2[CH:11]3[CH2:10][CH:9]([CH2:12]3)[N:8]3[C:13]([CH:20]([OH:32])[C:21]4[N:25]([CH:26]5[CH2:31][CH2:30][CH2:29][CH2:28][O:27]5)[N:24]=[CH:23][CH:22]=4)=[C:14]([C:16]([NH2:40])=[O:18])[N:15]=[C:7]3[C:6]=2[CH:33]=1

参加物

反応物 3

HCID 713Formamide

HCID 10942334Sodium Methoxide

HCID 86693468HCID 86693468、化合物

生成物 1

HCID 86693469HCID 86693469、化合物

実験手順

10-bromo-9-fluoro-3-(hydroxy(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)methyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide was prepared similarly to as described in General Procedure L. Methyl 10-bromo-9-fluoro-3-(hydroxy(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)methyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxylate was reacted with sodium methoxide and formamide to afford the crude title compound which was carried forward without further purification.

後処理

custom10-bromo-9-fluoro-3-(hydroxy(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)methyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide was prepared similarly

出典と根拠

ORDレコード: ord-f8a83c6153eb47c1bb1847367be5ed51
出典データセット: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09034866B2

反応ノート

読み込み中…