化工社化工社 化学情報印刷レポート · 研究参考用
HRID 575520作成日：2026年10月25日
Metformin Hydrochloride → 1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1)
https://huagongshe.com/reaction/575520
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Metformin Hydrochloride | HCID 14219 | — |
| 反応物 | Paraldehyde | HCID 31264 | — |
| 触媒 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 溶媒 | Isobutanol | HCID 6560 | — |
| 生成物 | 1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1) | HCID 10176486 | 183.1% |
反応手順
Synthesis according to the invention: A mixture of 1002.6 g of metformin hydrochloride, 359.1 g of paraldehyde and 51.6 g of toluene-4-sulfonic acid monohydrate in 2405.9 g of isobutanol was heated under reflux for 6 hours. Some of the solvent was removed by distillation. The mixture was cooled to 12° C., and the white precipitate was separated off, giving 953.8 g (81.4%) of 4-amino-3,6-dihydro-2-dimethylamino-6-methyl-1,3,5-triazine hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09035048B2 |
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| 出典データセット | uspto-grants-2015_05 |
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| ORD ID | ord-2cd48d6f605e40ae9c2565b7481c54c4 |
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| 出典メモ | uspto-grants-2015_05 |
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