Water → 1-Bromo-4-fluoro-2-methoxy-5-(methylsulfanylmethyl)benzene
反応式
[CH3:1][S-:2].[Br:3][C:4]1[CH:9]=[C:8]([CH2:10]Br)[C:7]([F:12])=[CH:6][C:5]=1[O:13][CH3:14].O.C(OCC)(=O)C>CN(C=O)C>[Br:3][C:4]1[CH:9]=[C:8]([CH2:10][S:2][CH3:1])[C:7]([F:12])=[CH:6][C:5]=1[O:13][CH3:14]参加物
6
実験手順
Thiomethoxide (1.19 g, 17.0 mmol) was added to a solution of 1-bromo-5-(bromomethyl)-4-fluoro-2-methoxybenzene (4.9 g, 16.4 mmol) in anhydrous DMF (25 mL) at 0° C. The mixture was stirred at room temperature for 5 h, and then poured into water (40 mL). Extractive work up with ethyl acetate gave the title compound (4.3 g, 99.0%) as colorless oil which was carried on without purification. 1H NMR (CDCl3, 400 MHz) δ 7.50 (d, J=8.0 Hz, 1H), 6.64 (d, J=11.2 Hz, 1H), 3.88 (s, 3H), 3.63 (s, 2H), 2.04 (s, 3H).
出典と根拠
- ORDレコード
- ord-be59ea13747b4da19013697f5ded70d7
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09034900B2
反応ノート
読み込み中…