p-Bromobenzenesulfonyl chloride → 4-[(4-Bromobenzene)sulfonyl]morpholine

HRID 57561

反応式

HRID 57561 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(N(CC)CC)C.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 8083MorpholineHCID 8471Triethylamine

生成物 1

HCID 2531284-[(4-Bromobenzene)sulfonyl]morpholine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-bromobenzene-1-sulfonyl chloride (2.56 g, 10.0 mmol) and triethylamine (1.82 mL, 13 mmol) in DCM (50 mL) was added morpholine (960 mg, 11.0 mmol) dropwise and the mixture was stirred for 30 minutes at room temperature. Then the mixture was concentrated and extracted with EA, washed with 0.1M HCl water solution (2×100 mL), NaHCO3 solution (2×100 mL) and brine, dried and concentrated to give product as a white solid.

後処理

  1. concentrationThen the mixture was concentrated
  2. extractionextracted with EA
  3. washwashed with 0.1M HCl water solution (2×100 mL), NaHCO3 solution (2×100 mL) and brine
  4. customdried
  5. concentrationconcentrated
  6. customto give product as a white solid

出典と根拠

ORDレコード
ord-9433996ce9ba462fa4ebac1f06a03aee
出典データセット
uspto-grants-2016_09
特許番号
US09434726B2

関連ノート

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