化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl Acetate → 4-Chloro-5-(2,4-difluorophenoxy)-2-methylsulfanylpyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 5-(2,4-Difluorophenoxy)-2-methylsulfanylpyrimidin-4-ol | HCID 178503474 | — |
| 触媒 | Tetramethylammonium chloride | HCID 6379 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-Chloro-5-(2,4-difluorophenoxy)-2-methylsulfanylpyrimidine | HCID 118021510 | 70.6% |
反応手順
The title compound of step 1 (5.30 g, 19.63 mmol), POCl3 (18.06 g, 117.78 mmol), (Me)4NCl (3.23 g, 29.47 mmol) in dry CH3CN (60 mL) was refluxed for 12 h. The mixture was poured into ice-water (50 mL) and subjected to EA extractive work up. Concentration under vacuum gave impure title compound (4.0 g), which was carried on to the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09034900B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-2f82fdc61f9b4b55907d79248a37c441 |
| 出典メモ | uspto-grants-2015_05 |