Hydrochloric Acid → HCID 118021890、化合物
反応式
[ClH:1].[C:2]1([NH:11]C(=O)OC(C)(C)C)[C:7]2[CH2:8][CH2:9][CH2:10][C:6]=2[CH:5]=[CH:4][N:3]=1>C(Cl)Cl>[ClH:1].[C:2]1([NH2:11])[C:7]2[CH2:8][CH2:9][CH2:10][C:6]=2[CH:5]=[CH:4][N:3]=1参加物
4
実験手順
Anhydrous 1M HCl in DCM (20 mL) was added slowly to the title compound of step 3 (570 mg, 2.43 mmol) in DCM (10 mL) at 0° C. After stirring at rt for 1.5 h, evaporation of the volatile components gave the title compound (400 mg, 96%) as a white solid. 1H NMR (CD3OD, 300 MHz): δ 7.66 (d, J=6.6 Hz, 1H), 6.88 (d, J=6.6 Hz, 1H), 3.04 (t, J=7.8, 7.2 Hz, 2H), 2.86 (t, J=7.8, 7.2 Hz, 2H), 2.17-2.27 (m, 2H). LCMS: 135 (M+1)+
後処理
- customevaporation of the volatile components
出典と根拠
- ORDレコード
- ord-e407f88a3b9746209e80ff7343f3e5eb
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09034900B2
反応ノート
読み込み中…