Lithium hydroxide, monohydrate → 3-(7-Chloropyrido[4,3-b]pyrazin-5-ylamino)propanoic acid
反応式
[Cl:1][C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][C:15]([O:17]C)=[O:16])[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[CH:3]=1.O[Li].O>CO.O>[Cl:1][C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[CH:3]=1参加物
4
実験手順
A solution of methyl 3-(7-chloropyrido[4,3-b]pyrazin-5-ylamino)propanoate (545 mg, 2.04 mmol) and LiOH.H2O (172 mg, 4.09 mmol) in MeOH/H2O (v. 20:1, 40 mL/2 mL) was stirred at room temperature for 20 hours. The volatiles were removed under reduced pressure, and the residue was acidified with HCl solution (1 N) till pH=2˜3. The precipitates were collected by filtration and dried to afford the title compound. MS (m/z): 253 (M+H)+.
後処理
- customThe volatiles were removed under reduced pressure
- filtrationThe precipitates were collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-17e0871514664230820bda7738433871
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434726B2
反応ノート
読み込み中…