2-Bromoethanol → 2-((4-Bromophenyl)(methyl)amino)ethanol
反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([NH:6][CH3:7])=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:17][CH2:18][OH:19]>CN(C=O)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([N:6]([CH3:7])[CH2:17][CH2:18][OH:19])=[CH:4][CH:3]=1参加物
5
実験手順
4-bromo-N-methylaniline (700 mg, 3.76 mmol) was dissolved in DMF (20 mL), K2CO3 (1.56 g, 11.29 mmol) and 2-bromoethanol (1.41 g, 11.29 mmol) were added in. The mixture was reacted at 100° C. for 2 days. Then it was extracted by EA and brine, washed by brine, dried over Na2SO4, concentrated and purified by flash chromatography, (PE: EA=10:1 to 3:1) to give 164 mg brown oil.
後処理
- customThe mixture was reacted at 100° C. for 2 days
- extractionThen it was extracted by EA and brine
- washwashed by brine
- dry with materialdried over Na2SO4
- concentrationconcentrated
- custompurified by flash chromatography, (PE: EA=10:1 to 3:1)
出典と根拠
- ORDレコード
- ord-6d589a2b258f454ab416792f893f1756
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434726B2
反応ノート
読み込み中…