Triethylamine → 4-Amino-2-({2-[(6-bromoimidazo[1,2-a]pyrazin-8-yl)amino]ethyl}amino)-1,3-thiazole-5-carbonitrile

関与物質

役割	名称	HCID	仕込み量
反応物	Triethylamine	HCID 8471	—
反応物	6,8-Dibromoimidazo[1,2-a]pyrazine	HCID 15025843	—
反応物	4-Amino-2-[(2-aminoethyl)amino]-1,3-thiazol-5-carbonitrile dihydrochloride	HCID 86651624	—
溶媒	Dimethyl Sulfoxide	HCID 679	—
生成物	4-Amino-2-({2-[(6-bromoimidazo[1,2-a]pyrazin-8-yl)amino]ethyl}amino)-1,3-thiazole-5-carbonitrile	HCID 86651625	—

反応条件

温度	140 °C

反応手順

300 mg (1.08 mmol) of 6,8-dibromoimidazo[1,2-a]pyrazine were dissolved in 10 ml of DMSO, and 0.6 ml (4.3 mmol) of triethylamine and 360 mg (1.3 mmol) of 4-amino-2-[(2-aminoethyl)amino]-1,3-thiazole-5-carbonitrile dihydrochloride (Example 8A) were added. The mixture was heated at 140° C. in a microwave for 1 h. Purification by preparative HPLC gave 376 mg (83% of theory) of the product as a solid.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09434731B2
出典データセット	uspto-grants-2016_09
ORD ID	ord-5bfda0b3f3b64eefb76a883114688c89
出典メモ	uspto-grants-2016_09