Hydrochloric Acid → HCID 86723846、化合物
反応式
[Si]([O:18][CH2:19][C@H:20]([N:22]1[C:27](=[O:28])[CH:26]=[CH:25][N:24]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=2)[C:23]1=[O:39])[CH3:21])(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1.Cl>C(O)C>[OH:18][CH2:19][C@H:20]([N:22]1[C:27](=[O:28])[CH:26]=[CH:25][N:24]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:36])[F:37])[CH:30]=2)[C:23]1=[O:39])[CH3:21]参加物
4
反応条件
- 温度
- 90 °C
実験手順
To a solution of (R)-3-[1-(tert-butyldiphenylsilyloxy)propane-2-yl]-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (prepared in Reference Example 101) (7.1 g) in ethanol (50.0 ml) was added 1N hydrochloric acid (64.0 ml) and the resulting mixture was stirred at 90° C. for two hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/methanol) to afford (R)-3-(1-hydroxypropan-2-yl)-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (2.6 g).