HCID 86723852、化合物 → HCID 86723854、化合物

HRID 576755ノート

反応式

HRID 576755 の反応式
[CH3:1][C:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[C:6](=[O:18])[N:5]([CH2:19][CH2:20][CH3:21])[C:4](=[O:22])[C:3]=1[N+:23]([O-])=O>CO.O.[Pd]>[NH2:23][C:3]1[C:4](=[O:22])[N:5]([CH2:19][CH2:20][CH3:21])[C:6](=[O:18])[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:17])[F:16])[CH:9]=2)[C:2]=1[CH3:1]

参加物

4

反応物 1

HCID 86723852HCID 86723852、化合物

生成物 1

HCID 86723854HCID 86723854、化合物収率 103.7%

試薬・触媒・溶媒 2

HCID 23219155Palladium hydrate触媒HCID 887Methanol溶媒

実験手順

To a solution of 6-methyl-5-nitro-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (200.0 mg) in methanol (10.0 ml) was added palladium hydrate (20.0 mg) and the resulting mixture was stirred at room temperature under catalytic hydrogenation condition for twelve hours. The reaction mixture was degassed and then filtered through Celite (trade mark), and then concentrated under reduced pressure to afford 5-amino-6-methyl-3-propyl-1-(3-trifluoromethylphenyl)pyrimidin-2,4(1H,3H)-dione (190.0 mg).

後処理

  1. customThe reaction mixture was degassed
  2. filtrationfiltered through Celite (trade mark)
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-53d5553a1d2845848b6862db8fb1d171
出典データセット
uspto-grants-2015_05
特許番号
US09040516B2

反応ノート

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