(S)-N-Cbz-1,1-diethoxypropan-2-amine → (2S)-1,1-Diethoxy-2-propanamine

HRID 576863ノート

反応式

HRID 576863 の反応式
[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH:7]C(=O)OCC1C=CC=CC=1)[CH3:6])[CH3:2]>CO>[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH2:7])[CH3:6])[CH3:2]

参加物

3

反応物 1

HCID 86652567(S)-N-Cbz-1,1-diethoxypropan-2-amine

生成物 1

HCID 12398111(2S)-1,1-Diethoxy-2-propanamine収率 100.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of (S)-benzyl 1,1-diethoxypropan-2-ylcarbamate (Compound XX-1) 844 mg (3.00 mmol) in methanol 50 ml, 5% palladium on carbon 30 mg was added and the mixture was stirred at room temperature for 2 hours under hydrogen atmosphere. The reaction mixture was filtered on celite and washed with methanol 200 ml and the mother solution was concentrated in vacuo to obtain the title compound 442 mg (1000).

後処理

  1. filtrationThe reaction mixture was filtered on celite
  2. washwashed with methanol 200 ml
  3. concentrationthe mother solution was concentrated in vacuo

出典と根拠

ORDレコード
ord-4c1dd4bb8ac34f2c81417c6e40c68a46
出典データセット
uspto-grants-2015_05
特許番号
US09040531B2

反応ノート

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