Phosphorus tribromide → 4-(Bromomethyl)-3,5-dimethyl-1,2-oxazole

HRID 576996

反応式

HRID 576996 の反応式
[CH3:1][C:2]1[C:6]([CH2:7]O)=[C:5]([CH3:9])[O:4][N:3]=1.P(Br)(Br)[Br:11]>ClCCl>[Br:11][CH2:7][C:6]1[C:2]([CH3:1])=[N:3][O:4][C:5]=1[CH3:9]

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 2895753,5-Dimethyl-4-(hydroxymethyl)isoxazole

生成物 1

HCID 127932894-(Bromomethyl)-3,5-dimethyl-1,2-oxazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (3,5-dimethyl-1,2-oxazol-4-yl)methanol (805 mg, 6.3 mmol) in anhydrous dichloromethane (60 mL) was added dropwise phosphorus tribromide (1.2 mL, 12.6 mmol). The mixture was stirred at room temperature for 3 hours. Dichloromethane was evaporated, and the residue was dried in vacuo, affording 4-(bromomethyl)-3,5-dimethyl-1,2-oxazole. The product was used without further purification.

後処理

  1. customDichloromethane was evaporated
  2. customthe residue was dried in vacuo

出典と根拠

ORDレコード
ord-d389b342ecea4aac9787e12d8cb485cb
出典データセット
uspto-grants-2015_05
特許番号
US09040538B2

関連ノート

読み込み中…