1,4-Dioxane hydrochloride → HCID 178462643、化合物
反応式
[CH2:1]([N:3]1[CH:7]=[CH:6][N:5]=[C:4]1[CH2:8][S:9][C:10]1[N:15]=[C:14]([OH:16])[CH:13]=[C:12]([CH3:17])[N:11]=1)[CH3:2].[ClH:18].O1CCOCC1>CO>[ClH:18].[ClH:18].[CH2:1]([N:3]1[CH:7]=[CH:6][N:5]=[C:4]1[CH2:8][S:9][C:10]1[N:15]=[C:14]([OH:16])[CH:13]=[C:12]([CH3:17])[N:11]=1)[CH3:2]参加物
4
実験手順
To a mixture of 2-{[(1-ethyl-1H-imidazol-2-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (215 mg, 0.86 mmol) in MeOH (3 mL) was added 4 M HCl/dioxane (2 mL, 8.0 mmol). The mixture became clear, and a solid precipitated. The solvent was evaporated. The solid product was dried in vacuo, affording the title compound (275 mg, 99% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.38 (t, 3H, J=7.2 Hz), 2.16 (s, 3H), 4.29 (m, 2H), 4.73 (s, 2H), 6.17 (s, 1H), 7.61 (d, 1H, J=2.0 Hz), 7.15 (d, 1H, J=2.0 Hz); M+ 251.