Potassium Carbonate → HCID 178429521、化合物

HRID 577037ノート

反応式

HRID 577037 の反応式
Cl.[Cl:2][C:3]1[N:7]([CH3:8])[C:6]([CH2:9]Cl)=[N:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:17][C:18]1[N:23]=[C:22]([SH:24])[N:21]=[C:20]([OH:25])[CH:19]=1>CC(C)=O>[Cl:2][C:3]1[N:7]([CH3:8])[C:6]([CH2:9][S:24][C:22]2[N:21]=[C:20]([OH:25])[CH:19]=[C:18]([CH3:17])[N:23]=2)=[N:5][CH:4]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 123115195-chloro-2-(chloromethyl)-1-methyl-1H-imidazole hydrochlorideHCID 178429541HCID 178429541、化合物

生成物 1

HCID 178429521HCID 178429521、化合物収率 79%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

5-chloro-2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride (1.0 g, 5.0 mmol), potassium carbonate (1.65 g, 12 mmol), and 6-methyl-2-sulfanylpyrimidin-4-ol (560 mg, 4.0 mmol) were mixed in acetone (20 mL). The mixture was stirred at room temperature overnight. Acetone was then removed under reduced pressure. The crude solid was purified by column chromatography to provide the title compound as a white solid (850 mg, 79% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.20 (s, 3H), 3.60 (s, 3H), 4.51 (s, 2H), 6.04 (br, 1H), 6.93 (s, 1H); M+ 271.

後処理

  1. customAcetone was then removed under reduced pressure
  2. customThe crude solid was purified by column chromatography

出典と根拠

ORDレコード
ord-4aa706d1948e4be08531e647278a6beb
出典データセット
uspto-grants-2015_05
特許番号
US09040538B2

反応ノート

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