Bromine → Ethyl 2-bromo-4-methyl-3-oxopentanoate
反応式
[CH3:1][CH:2]([CH3:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[Br:12]Br>O>[Br:12][CH:4]([C:3](=[O:10])[CH:2]([CH3:1])[CH3:11])[C:5]([O:7][CH2:8][CH3:9])=[O:6]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a 0° C. solution of ethyl 4-methyl-3-oxopentanoate (5.0 mL, 31 mmol) in water (20 mL) was added bromine (16 mL, 31.3 mmol) via syringe pump (0.5 hour). The mixture was stirred at 0° C. for 0.5 hour. The solution was extracted with EtOAc (3×20 mL). The organic extracts were combined, extracted with brine (2×60 mL), dried over MgSO4, filtered, evaporated, and dried in vacuo, affording ethyl 2-bromo-4-methyl-3-oxopentanoate (6.0 g, 82% yield). The product was used without further purification.
後処理
- extractionThe solution was extracted with EtOAc (3×20 mL)
- extractionextracted with brine (2×60 mL)
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-bfd526e0682b4e919d019679243a8dd3
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09040538B2
反応ノート
読み込み中…