Phosphorus tribromide → 3-(bromomethyl)-4-chloro-1-methyl-1H-pyrazole

HRID 577142ノート

反応式

HRID 577142 の反応式
[Cl:1][C:2]1[C:3]([CH2:8]O)=[N:4][N:5]([CH3:7])[CH:6]=1.[Br:10]P(Br)Br>ClCCl>[Br:10][CH2:8][C:3]1[C:2]([Cl:1])=[CH:6][N:5]([CH3:7])[N:4]=1

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 55255171(4-chloro-1-methyl-1H-pyrazol-3-yl)methanol

生成物 1

HCID 595893993-(bromomethyl)-4-chloro-1-methyl-1H-pyrazole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of (4-chloro-1-methyl-1H-pyrazol-3-yl)methanol (680 mg, 4.7 mmol) in anhydrous dichloromethane (25 mL) was added dropwise a solution of tribromophosphane (450 μL, 4.7 mmol) in anhydrous dichloromethane (5 mL) at 0° C. The mixture was stirred for 1 hour at room temperature and then was evaporated to yield 3-(bromomethyl)-4-chloro-1-methyl-1H-pyrazole, which was used in the next step without further purification.

後処理

  1. customwas evaporated

出典と根拠

ORDレコード
ord-6ade33f73291478496e51398d634c3b4
出典データセット
uspto-grants-2015_05
特許番号
US09040538B2

反応ノート

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