Phosphorus tribromide → HCID 66815164、化合物
反応式
[CH2:1]([C:3]1[CH:4]=[N:5][CH:6]=[C:7]([F:11])[C:8]=1[CH2:9]O)[CH3:2].[Br:12]P(Br)Br>ClCCl>[BrH:12].[Br:12][CH2:9][C:8]1[C:7]([F:11])=[CH:6][N:5]=[CH:4][C:3]=1[CH2:1][CH3:2]参加物
4
実験手順
To a solution of (3-ethyl-5-fluoropyridin-4-yl)methanol (1.5 g, 9.7 mmol) in anhydrous dichloromethane (75 mL) was added tribromophosphane (1 mL, 10.5 mmol). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated. The residue was dried in vacuo, affording 4-(bromomethyl)-3-ethyl-5-fluoropyridine hydrobromide. The crude product was used without further purification.
後処理
- customDichloromethane was evaporated
- customThe residue was dried in vacuo
出典と根拠
- ORDレコード
- ord-17aa1209a5b04bfc96250b3abf4f5094
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09040538B2
反応ノート
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