Diethylamine → Methyl 2-chloro-6-[(diethylamino)methyl]benzoate

HRID 577215ノート

反応式

HRID 577215 の反応式
Br[CH2:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:4]=1[C:5]([O:7][CH3:8])=[O:6].[CH2:14]([NH:16][CH2:17][CH3:18])[CH3:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:13][C:9]1[CH:10]=[CH:11][CH:12]=[C:3]([CH2:2][N:16]([CH2:17][CH3:18])[CH2:14][CH3:15])[C:4]=1[C:5]([O:7][CH3:8])=[O:6]

参加物

5

反応物 3

HCID 8021DiethylamineHCID 11430Potassium CarbonateHCID 22935208Methyl 2-(bromomethyl)-6-chlorobenzoate

生成物 1

HCID 59589357Methyl 2-chloro-6-[(diethylamino)methyl]benzoate収率 99.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of methyl 2-(bromomethyl)-6-chlorobenzoate (4.0 g, 15.6 mmol), diethylamine (5 mL, 48.1 mmol), and potassium carbonate (4.3 g, 31.2 mmol) in acetone (60 mL) was stirred at room temperature for 2 days. The solid material was removed by filtration. The filtrate was recovered, evaporated, and dried in vacuo, affording methyl 2-chloro-6-[(diethylamino)methyl]benzoate (3.97 g, 99% yield), which was used without further purification.

後処理

  1. customThe solid material was removed by filtration
  2. customThe filtrate was recovered
  3. customevaporated
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-cec46471cd2e461080a66033527a5ab4
出典データセット
uspto-grants-2015_05
特許番号
US09040538B2

反応ノート

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