Triethylamine → HCID 178430797、化合物

HRID 577219ノート

反応式

HRID 577219 の反応式
Br[CH2:2][C:3]1[C:8]([Cl:9])=[CH:7][N:6]=[CH:5][C:4]=1[Cl:10].[CH3:11][C:12]1[C:13]([OH:19])=[N:14][C:15]([SH:18])=[N:16][CH:17]=1.C(N(CC)CC)C>C(O)C>[Cl:10][C:4]1[CH:5]=[N:6][CH:7]=[C:8]([Cl:9])[C:3]=1[CH2:2][S:18][C:15]1[N:14]=[C:13]([OH:19])[C:12]([CH3:11])=[CH:17][N:16]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 222277664-(Bromomethyl)-3,5-dichloropyridineHCID 178430804HCID 178430804、化合物

生成物 1

HCID 178430797HCID 178430797、化合物収率 100.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a mixture of 4-(bromomethyl)-3,5-dichloropyridine (1.0 g, 4.15 mmol) and 5-methyl-2-sulfanylpyrimidin-4-ol (0.38 g, 2.69 mmol) in anhydrous ethanol (25 mL) at 0° C. was added triethylamine (1.67 g, 16.6 mmol). The reaction mixture was stirred at room temperature overnight. The solvent was evaporated, water was added, and the mixture was sonicated and then filtered. The solid was washed with water and hexane to provide 2-{[(3,5-dichloropyridin-4-yl)methyl]sulfanyl}-5-methylpyrimidin-4-ol (0.817 g, 65% yield); 1H NMR (400 MHz, DMSO-d6): δ 1.90 (s, 3H), 4.66 (s, 2H), 7.99 (s 1H), 8.66 (s, 2H); M+ 302.5.

後処理

  1. customThe solvent was evaporated
  2. additionwater was added
  3. customthe mixture was sonicated
  4. filtrationfiltered
  5. washThe solid was washed with water and hexane

出典と根拠

ORDレコード
ord-d39317d828014e3b9dac42cbd39f0472
出典データセット
uspto-grants-2015_05
特許番号
US09040538B2

反応ノート

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