Bromine → Ethyl 2-bromo-3-oxopentanoate
反応式
[O:1]=[C:2]([CH2:9][CH3:10])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[Br:11]Br>O>[Br:11][CH:3]([C:2](=[O:1])[CH2:9][CH3:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a 0° C. solution of ethyl 3-oxopentanoate (5.0 mL, 34.7 mmol) in water (30 mL) was added bromine (1.8 mL, 35.0 mmol) via syringe pump (0.5 hour). The mixture was stirred at 0° C. for 0.5 hour. The solution was extracted with EtOAc (2×35 mL). The organic extracts were combined, dried over MgSO4, filtered, evaporated, and dried in vacuo, affording ethyl 2-bromo-3-oxopentanoate (7.3 g, 94% yield). The product was used without further purification.
後処理
- extractionThe solution was extracted with EtOAc (2×35 mL)
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-7065dc4dd39d464483aca5f0ba54ec21
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09040538B2
反応ノート
読み込み中…