(R)-2-amino-3-methylbutanamide → HCID 178480102、化合物

HRID 577430

反応式

HRID 577430 の反応式
[NH2:1][C:2](=O)[C@H:3]([NH:7][C:8]1[N:9]=[N:10][C:11]([C:25]([NH2:27])=[O:26])=[C:12]([NH:14][C:15]2[CH:23]=[CH:22][CH:21]=[C:20]3[C:16]=2[CH:17]=[CH:18][N:19]3[CH3:24])[N:13]=1)C(C)C.[NH:29]1[CH:33]=[CH:32]C(CN)=N1.N[C@H](C(C)C)C(N)=O>>[NH:29]1[CH:33]=[CH:32][C:2]([CH2:3][NH:7][C:8]2[N:9]=[N:10][C:11]([C:25]([NH2:27])=[O:26])=[C:12]([NH:14][C:15]3[CH:23]=[CH:22][CH:21]=[C:20]4[C:16]=3[CH:17]=[CH:18][N:19]4[CH3:24])[N:13]=2)=[N:1]1

参加物

4

反応物 3

HCID 444079(R)-2-amino-3-methylbutanamideHCID 86706423(R)-3-((1-amino-3-methyl-1-oxobutan-2-yl)amino)-5-((1-methyl-1H-indol-4-yl)amino)-1,2,4-triazine-6-carboxamideHCID 178510230HCID 178510230、化合物

生成物 1

HCID 178480102HCID 178480102、化合物

実験手順

The title compound was prepared in a similar procedure as described in Example (R)-3-((1-amino-3-methyl-1-oxobutan-2-yl)amino)-5-((1-methyl-1H-indol-4-yl)amino)-1,2,4-triazine-6-carboxamide. Here though, 1H-Pyrazole-3-methanamine was utilized instead of (R)-2-amino-3-methylbutanamide. MS found for C17H17N9O as (M+H)+ 364.4. UV: λ=211, 239 nm. Proton NMR: (CD3OD) δ 7.90 (1H, d, J=8.0 Hz), 7.62 (1H, m), 7.34 (1H, d, J=8.8 Hz), 7.28 (1H, d, J=3.2 Hz), 7.20 (1H, t, J=8.0 Hz), 6.63 (1H, d, J=3.6 Hz), 6.33 (1H, m), 4.76 (2H, m), 3.85 (3H, s) ppm.

出典と根拠

ORDレコード
ord-37eec7ec952a47a0afaf2f2c7a855757
出典データセット
uspto-grants-2015_05
特許番号
US09040530B2

関連ノート

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