Potassium Hydroxide → 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-7-(difluoromethoxy)-3,4-dihydroisoquinolin-1(2H)-one

反応式

[CH2:1]([O:8][C:9]1[C:14]([CH2:15][N:16]2[CH2:25][CH2:24][C:23]3[C:18](=[C:19]([Cl:27])[C:20]([OH:26])=[CH:21][CH:22]=3)[C:17]2=[O:28])=[C:13]([CH3:29])[CH:12]=[C:11]([CH3:30])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].Br[C:34](P(=O)(OCC)OCC)([F:36])[F:35]>CC#N.O.CCOC(C)=O.O>[CH2:1]([O:8][C:9]1[C:14]([CH2:15][N:16]2[CH2:25][CH2:24][C:23]3[C:18](=[C:19]([Cl:27])[C:20]([O:26][CH:34]([F:36])[F:35])=[CH:21][CH:22]=3)[C:17]2=[O:28])=[C:13]([CH3:29])[CH:12]=[C:11]([CH3:30])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1