Hydrochloric Acid → Methyl 3-bromo-6-(2-hydroxyethoxy)-2-methylbenzoate

HRID 577569ノート

反応式

HRID 577569 の反応式
[Br:1][C:2]1[C:3]([CH3:22])=[C:4]([C:9]([O:12][CH2:13][CH2:14][O:15]C2CCCCO2)=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].Cl>CO>[Br:1][C:2]1[C:3]([CH3:22])=[C:4]([C:9]([O:12][CH2:13][CH2:14][OH:15])=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86723693methyl 3-bromo-2-methyl-6-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]benzoate

生成物 1

HCID 86723795Methyl 3-bromo-6-(2-hydroxyethoxy)-2-methylbenzoate収率 110%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of methyl 3-bromo-2-methyl-6-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]-benzoate (Cpd HH, 162 mg, 0.434 mmol) in MeOH (4 mL) was treated with 6N HCl (0.2 mL) and stirred at room temperature for 30 minutes. The solvent was concentrated in vacuum to 1 mL and the solution partitioned between DCM (25 mL) and NaHCO3 (sat., aq., 25 mL). The organic layer was concentrated under vacuum to give methyl 3-bromo-6-(2-hydroxyethoxy)-2-methylbenzoate (126a, 138 mg, 110% yield) as a colorless oil.

後処理

  1. concentrationThe solvent was concentrated in vacuum to 1 mL
  2. customthe solution partitioned between DCM (25 mL) and NaHCO3 (sat., aq., 25 mL)
  3. concentrationThe organic layer was concentrated under vacuum

出典と根拠

ORDレコード
ord-82e81d7a35d043ebabf23995d0eabdc3
出典データセット
uspto-grants-2015_05
特許番号
US09040515B2

反応ノート

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