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Ethyl isothiocyanatoformate → Ethyl aminon-(3-bromopyridin-2-YL)methanethiocarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl isothiocyanatoformate | HCID 85320 | — |
| 反応物 | 2-Amino-3-bromopyridine | HCID 817700 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Ethyl aminon-(3-bromopyridin-2-YL)methanethiocarbamate | HCID 59199107 | 100.1% |
反応手順
To a solution of 2-amino-3-bromopyridine (50.0 g, 289 mmol, 1 equiv) in dichloromethane (500 mL) was added dropwise ethoxycarbonyl isothiocyanate (39.0 g, 297 mmol, 1.03 equiv) at room temperature. After 2 h, dichloromethane was removed in vacuo to provide crude ethyl [(3-bromopyridin-2-yl) carbamothioyl]carbamate (88 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434732B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-3f38827b80af4bdb9a6ae3cdfa4213f7 |
| 出典メモ | uspto-grants-2016_09 |