Hydrochloric Acid → 3-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylic acid

HRID 577735

反応式

HRID 577735 の反応式
[OH-].[K+].[CH3:3][N:4]([CH3:19])[CH2:5][CH2:6][O:7][C:8]1[CH:12]=[C:11]([C:13]([O:15]CC)=[O:14])[N:10]([CH3:18])[N:9]=1.Cl>CCO>[CH3:3][N:4]([CH3:19])[CH2:5][CH2:6][O:7][C:8]1[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[N:10]([CH3:18])[N:9]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 86679667ethyl 3-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylate

生成物 1

HCID 866796683-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylic acid収率 83%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

KOH (2.09 g, 37.4 mmol) was dissolved into EtOH (30 mL) and to this solution was added ethyl 3-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylate (4.5 g, 18.7 mmol) and the mixture stirred at rt overnight. To the reaction mixture was added concentrated HCl (3.1 mL) with stirring and the resulting suspension was filtered and the cake was washed with EtOH (two×20 mL). The filtrate was concentrated to give the title compound (3.3 g, 83% yield) as a brown gum.

後処理

  1. stirringwith stirring
  2. filtrationthe resulting suspension was filtered
  3. washthe cake was washed with EtOH (two×20 mL)
  4. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-4cbb75141e2b445bbc33bf5a0397755d
出典データセット
uspto-grants-2015_05
特許番号
US09040547B2

関連ノート

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