C(=O)([O-])[O-].[K+].[K+].[C:7]([NH:9][CH:10]=[N:11][CH:12]1[C:20]2[C:15](=[C:16]([Cl:21])[CH:17]=[CH:18][CH:19]=2)[CH2:14][C:13]1([CH3:23])[CH3:22])#N.Br[CH2:25][C:26]([O:28][CH3:29])=[O:27]>CN(C)C=O>[CH3:29][O:28][C:26]([C:25]1[N:11]([CH:12]2[C:20]3[C:15](=[C:16]([Cl:21])[CH:17]=[CH:18][CH:19]=3)[CH2:14][C:13]2([CH3:23])[CH3:22])[CH:10]=[N:9][CH:7]=1)=[O:27]12.7 g of potassium carbonate are added to a solution of 21 g of N-cyano-N'-(2,2-dimethyl-4-chloroindan-1-yl)formamidine in 80 ml of dimethylformamide. 14.1 g of methyl bromoacetate are added dropwise. After the exothermic reaction has ceased the mixture is agitated for 1.5 hours at +50° C. another portion of 12.7 g of potassium carbonate is added and the mixture is stirred for 18 hours at +100° C. The precipitate is filtered off from the hot solution and washed with 30 g of hot dimethylformamide. The combined filtrates are dropwise added at +60° C. to a solution of 14.2 g of tert. butylnitrite in 30 ml of dimethylformamide. Immediate evolution of nitrogen is observed and the temperature of the mixture rises to +67° C. After 30 minutes the dropwise addition is completed. The mixture is maintained at +70° to +75° C. for 2.5 hours and then poured into ice-water and extracted with ethyl acetate. The organic phase is washed with brine, dried with sodium sulfate and concentrated to dryness. The residue is purified by chromatography at a silica gel column with an ethyl acetate/hexane mixture (1:2 by volume), affording 12.7 g of 1-(2,2-dimethyl-4-chloro-indan-1-yl)-5-imidazolecarboxylic acid methyl ester, having a melting point of 111°-113° C.
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