Benzylamine → 1-[(Phenylmethyl)amino]-2-butanol
反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:9]1[CH:11]([CH2:12][CH3:13])[CH2:10]1>C(O)C>[CH2:1]([NH:8][CH2:10][CH:11]([OH:9])[CH2:12][CH3:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 150 °C
実験手順
To a solution of benzylamine (29.65 g, 277.0 mmol) in ethanol (40 mL) was added 1,2-epoxybutane (4 g, 55.47 mmol) and the mixture was heated to 150° C. for 2 h in a autoclave. It was concentrated and distilled at 140-150° C./2 mm Hg to give product as color less liquid, which slowly crystallizes at room temperature after 2 days. Yield: 8.5 g (85%)
後処理
- concentrationIt was concentrated
- distillationdistilled at 140-150° C./2 mm Hg
- customto give product as color less liquid, which
- customslowly crystallizes at room temperature after 2 days
出典と根拠
- ORDレコード
- ord-b36cf9d0e5144a5eaa661d2ee64d0615
- 出典データセット
- uspto-grants-2015_05
- 特許番号
- US09040528B2
反応ノート
読み込み中…