Ammonia → 3-(pyridin-3-yl)-5-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1,2,4-oxadiazole

反応式

[NH:1]1[C:5]2=[N:6][CH:7]=[C:8]([C:10]([OH:12])=O)[CH:9]=[C:4]2[CH:3]=[CH:2]1.O[N:14]=[C:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1.N>>[N:18]1[CH:19]=[CH:20][CH:21]=[C:16]([C:15]2[N:22]=[C:10]([C:8]3[CH:9]=[C:4]4[CH:3]=[CH:2][NH:1][C:5]4=[N:6][CH:7]=3)[O:12][N:14]=2)[CH:17]=1

参加物

反応物 3

HCID 222Ammonia

HCID 308113N-Hydroxynicotinimidamide

HCID 219070181H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid

生成物 1

HCID 445449643-(pyridin-3-yl)-5-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1,2,4-oxadiazole

実験手順

The title compound was prepared according to Method C using 1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid (Adesis) and N′-hydroxynicotinimidamide (Tyger). 1H NMR (300 MHz, DMSO-d6) δ 6.71 (d, J=3.4 Hz, 1H), 7.66 (ddd, J=7.9, 4.8, 0.8 Hz, 1H), 7.70 (d, J=3.4 Hz, 1H), 8.47 (dt, J=8.1, 1.9 Hz, 1H), 8.78-8.86 (m, 2H), 9.05 (d, J=2.0 Hz, 1H), 9.28 (dd, J=2.2, 0.8 Hz, 1H) ppm; MS (DCI/NH3) m/z 264 (M+H)+.

出典と根拠

ORDレコード: ord-b4f03e8dc7204f3692434d0ce0280974
出典データセット: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09040568B2

反応ノート

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