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Hydrochloric Acid → 1-tert-Butyl-1H-pyrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Tetramethoxypropane | HCID 66019 | — |
| 反応物 | tert-Butylhydrazine monohydrochloride | HCID 81889 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-tert-Butyl-1H-pyrazole | HCID 13469815 | 89.1% |
反応手順
A mixture of 1,1,3,3-tetramethoxypropane (3.7 g, 22.6 mmol), tert-butylhydrazine hydrochloride (2.8 g, 22.6 mmol), and conc. HCl (6 mL, 72 mmol) in EtOH (30 mL) was heated at reflux overnight. The reaction mixture was poured into water and the resulting mixture was extracted with ether (30 mL×3). The combined organics was washed with brine (20 mL), dried over MgSO4, and concentrated under reduced pressure to afford 1-tert-butyl-1H-pyrazole as a white solid (2.5 g, 89%). MS (ESI) m/z: 125 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434725B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-6a335cf3c39a4015825d004aca41beae |
| 出典メモ | uspto-grants-2016_09 |