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Water → 2-Tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Methylpiperidine | HCID 69381 | — |
| 反応物 | 2-Tert-butyl-5-chloro-6-nitrobenzothiazole | HCID 19794202 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-Tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole | HCID 19794189 | — |
反応手順
A solution of 32,4 g of 2-tert-butyl-5-chloro-6-nitrobenzothiazole, (described in European patent application 85810418.5 published under No. 0175650) in 300 ml of dimethylsulphoxide, is stirred and heated at 140° for 6 hours with 12.8 g of 4-methylpiperidine and 35.8 g of anhydrous potassium carbonate, cooled and poured into water. The solid obtained is dissolved in chloroform and filtered through a silical gel column. The filtate is evaporated to give 2-tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole melting at 116°-120°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05246927 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-269df9c1e534472b9cb72738c8208fee |
| 出典メモ | uspto-grants-1993_09 |