2-(6-Bromopyridin-3-yl)acetonitrile → 4-[3-(5-Cyanomethyl-pyridin-2-ylamino)-benzylamino]-quinazoline-8-carboxylic acid amide
反応式
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[CH2:6][NH:7][C:8]1[C:17]2[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=2)[N:11]=[CH:10][N:9]=1.Br[C:25]1[N:30]=[CH:29][C:28]([CH2:31][C:32]#[N:33])=[CH:27][CH:26]=1>>[C:32]([CH2:31][C:28]1[CH:27]=[CH:26][C:25]([NH:2][C:3]2[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=2)[CH2:6][NH:7][C:8]2[C:17]3[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=3)[N:11]=[CH:10][N:9]=2)=[N:30][CH:29]=1)#[N:33]参加物
3
実験手順
The title compound was prepared according to Example 616 starting 4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride and (6-Bromo-pyridin-3-yl)-acetonitrile.
出典と根拠
- ORDレコード
- ord-0373b22fd8de4562b38d2e71d19afe1f
- 出典データセット
- uspto-grants-2015_05