4-Methoxybenzoic Acid → 4-[5-(4-Methoxy-benzoylamino)-2-methyl-benzylamino]-quinazoline-8-carboxylic acid amide

HRID 578703ノート

反応式

HRID 578703 の反応式
COC1C=CC(C(N(C)C2C=C(C=CC=2)CN[C:15]2[C:24]3[C:19](=[C:20]([C:25]([NH2:27])=[O:26])[CH:21]=[CH:22][CH:23]=3)[N:18]=[CH:17][N:16]=2)=O)=CC=1.[NH2:34][C:35]1[CH:36]=[CH:37][C:38]([CH3:43])=[C:39]([CH:42]=1)[C:40]#[N:41].[CH3:44][O:45][C:46]1[CH:54]=[CH:53][C:49]([C:50](O)=[O:51])=[CH:48][CH:47]=1>>[CH3:44][O:45][C:46]1[CH:54]=[CH:53][C:49]([C:50]([NH:34][C:35]2[CH:36]=[CH:37][C:38]([CH3:43])=[C:39]([CH:42]=2)[CH2:40][NH:41][C:15]2[C:24]3[C:19](=[C:20]([C:25]([NH2:27])=[O:26])[CH:21]=[CH:22][CH:23]=3)[N:18]=[CH:17][N:16]=2)=[O:51])=[CH:48][CH:47]=1

参加物

4

反応物 3

HCID 74784-Methoxybenzoic AcidHCID 27353655-Amino-2-methylbenzonitrileHCID 667640754-{3-[(4-Methoxy-benzoyl)-methyl-amino]-benzylamino}-quinazoline-8-carboxylic acid amide

生成物 1

HCID 667624914-[5-(4-Methoxy-benzoylamino)-2-methyl-benzylamino]-quinazoline-8-carboxylic acid amide

実験手順

4-[5-(4-Methoxy-benzoylamino)-2-methyl-benzylamino]-quinazoline-8-carboxylic acid amide was prepared according to example 4-{3-[(4-Methoxy-benzoyl)-methyl-amino]-benzylamino}-quinazoline-8-carboxylic acid amide, starting from 5-Amino-2-methyl-benzonitrile and 4-methoxy-benzoic acid:

出典と根拠

ORDレコード
ord-7a230a7d454b4c3880f54edcdb9bc177
出典データセット
uspto-grants-2015_05
特許番号
US09040560B2

反応ノート

読み込み中…