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Water → 2-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1-Methylpiperazine | HCID 53167 | — |
| 反応物 | N-t-butylthiocarbonyl-2,5-dichloro-4-nitroaniline | HCID 54175336 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 2-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole | HCID 19794200 | — |
反応手順
A solution of 171 g of N-tert-butylthiocarbonyl-2,5-dichloro-4-nitroaniline (described in European patent application No. 85810418.5 published under No. 0175650) and 605 ml of N-methylpiperazine in 1700 ml of dimethylsulphoxide is heated at 140° for 8 hours, cooled and poured into water. The solid is filtered, washed with water and cold isopropanol to yield 2-tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole, melting at 132°-135°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05246927 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-8d6c5e55a6af4dfdb2e2e90fcdc60967 |
| 出典メモ | uspto-grants-1993_09 |