化工社化工社 化学情報印刷レポート · 研究参考用
Benzylamine → N-Benzyl-6-chloro-nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzylamine | HCID 7504 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 6-Chloronicotinic acid | HCID 79222 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-Benzyl-6-chloro-nicotinamide | HCID 857488 | 636.4% |
反応手順
Combined 6-chloronicotinic acid (20 g, 12.74 mmol) and HATU (72.6 g, 19.1 mmol) in DMF (200 mL) and added triethylamine (38.6 g, 38.2 mmol) drop wise, followed by benzylamine (16.36 g, 15.28 mmol) and stirred at room temperature overnight. Then the reaction mixture was poured into ice-water and stirred for 20 minutes to give a solid. The solid was collected by filtration, washed with water (30 mL×2), and dried under reduced pressure to give the title compound (20 g, 64%) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09040522B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-1ac1805544854fac96d811f5df2bf6da |
| 出典メモ | uspto-grants-2015_05 |