Dimethylformamide dimethyl acetal → Methyl 2-(4-cyano-5-fluoro-2-methylphenyl)-3-(dimethylamino)acrylate

反応式

[C:1]([C:3]1[C:8]([F:9])=[CH:7][C:6]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[C:5]([CH3:15])[CH:4]=1)#[N:2].CO[CH:18](OC)[N:19]([CH3:21])[CH3:20].[Cl-].[Li+]>CCOC(C)=O>[C:1]([C:3]1[C:8]([F:9])=[CH:7][C:6]([C:10](=[CH:18][N:19]([CH3:21])[CH3:20])[C:11]([O:13][CH3:14])=[O:12])=[C:5]([CH3:15])[CH:4]=1)#[N:2]

参加物

実験手順

Combined methyl 2-(4-cyano-5-fluoro-2-methylphenyl)acetate (5.00 g, 24.13 mmol), 1,1-dimethoxy-N,N-dimethylmethanamine (32.2 mL, 241 mmol), and lithium chloride (0.102 g, 2.413 mmol) and heated to 105° C. After 2 hours the reaction mixture was concentrated in vacuo and repeatedly diluted with EtOAc (30 mL) and concentrated to give an oil. The oil was dissolved in EtOAc (50 mL) and washed with water, 10% aqueous sodium chloride, and then brine. The organic layer was dried over sodium sulfate, filtered, and concentrated to afford a thick red oil, which was crystallized to give the title compound as a yellow solid (6.1 g, 23.26 mmol, 96%). 1H NMR (400 MHz, DMSO-d6) δ ppm 2.10 (s, 3 H) 2.34 (s, 1 H) 2.54-2.81 (m, 6 H) 3.50 (s, 3 H) 7.20 (d, J=10.11 Hz, 1 H) 7.58 (s, 1 H) 7.72 (d, J=7.07 Hz, 1 H). ESI-MS m/z [M+H]+ 263.2.