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2-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole → 6-Amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Tert-butyl-5-(4-methylpiperazin-1-yl)-6-nitrobenzothiazole | HCID 19794200 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 6-Amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole | HCID 19794176 | — |
反応手順
A solution of 86 g of the above nitro compound in 150 ml of ethanol is hydrogenated in presence of 30 g of Raney nickel at 45°. The solution is filtered to give 6-amino-2-tert-butyl-5-(4-methylpiperazin-1-yl)benzothiazole, melting at 130° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05246927 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-c4b9469cd7684e858e4abf2ec83970cc |
| 出典メモ | uspto-grants-1993_09 |